DRUG INTERACTIONS: Amitriptyline should not be used with monoamine oxidase inhibiting drugs. High fever, convulsions and even death can occur when these two drugs are used together. Epinephrine should not be used with amitriptyline, since together they can cause severe high blood pressure. Alcohol blocks the antidepressant action of amitriptyline but increases its sedative effect. Cimetidine (Tagamet) can increase blood levels of amitriptyline and its side effects.

BRAND NAME: Endep (Elavil: This brand name drug is no longer available in the U.S.)

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Amitriptyline is an antidepressant drug. Depression is an all-pervasive sense of sadness and gloom. It is believed that in some patients with depression, abnormal levels of neurotransmitters (chemicals that nerves use to communicate with each other) may relate to their depression. Amitriptyline elevates mood by raising the level of neurotransmitters in nerves of the brain. Amitriptyline was approved by the FDA in May 1983.

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Antidepressant Elavil